Background: Hyperuricemia has been reported to be associated with chronic kidney disease (CKD). However\nwhether an elevated serum uric acid level is an independent risk factor for new-onset CKD remained controversial.\nMethods: A systematic review and meta-analysis using a literature search of online databases including PubMed,\nEmbase, Ovid and ISI Web/Web of Science was conducted. Summary adjusted odds ratios with corresponding 95%\nconfidence intervals (95% CI) were calculated to evaluate the risk estimates of hyperuricemia for new-onset CKD.\nResults: Thirteen studies containing 190,718 participants were included. A significant positive association was found\nbetween elevated serum uric acid levels and new-onset CKD at follow-up (summary OR, 1.15; 95% CI, 1.05ââ?¬â??1.25).\nHyperuricemia was found be an independent predictor for the development of newly diagnosed CKD in non-CKD\npatients (summary OR, 2.35; 95% CI, 1.59ââ?¬â??3.46). This association increased with increasing length of follow-up. No\nsignificant differences were found for risk estimates of the associations between elevated serum uric acid levels and\ndeveloping CKD between males and females.\nConclusions: With long-term follow-up of non-CKD individuals, elevated serum uric acid levels showed an\nincreased risk for the development of chronic renal dysfunction.
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